Printable Version
A63
October 14, 2006
9:00 AM - 11:00 AM
Room Hall E, Area B
The Influence of Tramadol and Fentanyl on Postoperative Sleep Pattern
Xiaokui Li, M.D., Tianzuo Li, M.D., Bingxi Zhang, M.D.
Anesthesiology, Tongren Hospital, Beijing, China
Objective To prevent the postoperative sleep disorder is propitious to the postoperative recovery. The purpose of this study was to compare the influence of tramadol and fentanyl as postoperative analgesic on postoperative sleep pattern.
Methods 45 patients diagnosed as obstructive sleep apnea syndrome underwent uvulopalatopharyngoplasty (UPPP) were involved and allocated into 3 groups randomly according to the different medication, n=15 each. Patient controlled intravenous analgesia (PCIA) was employed after recovery from anesthesia. GroupI(with tramadol, initial dose 50mg, background rate10mg/hr, lock time 10 min, bolus dose 10mg), groupII(with fentanyl, initial dose 50μg, background rate10μg/hr, lock time 10min, bolus dose 10μg) and group III (control group, with placebo). Polysomnography (PSG) was recorded during the first night after operation; visual analgesia scale (VAS) at time point of 6hr was also recorded. ANOVA was used for data analysis.
Results VAS of GroupI(3.2±1.1) and groupII(2.9±1.4)were significantly lower than that in control group (7.2±2.2), P<0.05. Slow wave sleep (SWS) and total sleep time (TST) in tramadol group were 33.06±7.56 min and 197.4±84.48 min, those in fentanyl group were 9.2±7.26 min and 148.33±72.73 min, while those in control group were 13.0±4.68 min and 124.13±61.38 min. SWS and TST in tramadol group were significantly longer than those in control group, P<0.05. Conclusions Both tramadol and fentanyl can provide satisfactory analgesia postoperatively. Interestingly, relief of pain per se can not prolong TST and SWS. Tramadol seems to have effect of prolonging SWS and TST, which favors maintaining of normal sleep pattern postoperatively, while fentanyl has no such effect.
Anesthesiology 2006; 105: A63
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se qualcuno soffre di insonnia qua dice che ,il miglior sonnifero è il tramadolo!? se ho ben capito, mi giunge nuova, pensavo il contrario a me è capitato di prenderlo la mattina ma di sonno zero....poi so che agisce anche su nora e sero ....mAH......